Category: Purchase article

Angiotherapeutic effects of orciprenaline after ischemic spinal cord injury: down-regulation of MAPK signaling in animal model Pathophysiology of Cell Injury Journal  Volume 5, Issue 1, pages 56-64 Received October 12, 2015; accepted May 02, 2016; published June 27, 2016  Christina Ballantyne¹’², Haohao Chen¹’³, Jin GAO¹, Liping Liu¹, Yongjun Lee¹*   Abstract Because there is no curative treatment for ischemic spinal cord (SCI), investigating animal model is highlight to assess therapies for […]

α-Tocopherol improved myocardial hypertrophy through suppression angiogenesis process in rat model Pathophysiology of Cell Injury Journal  Volume 5, Issue 1, pages 40-55 Received November 28, 2015; accepted April 30, 2016; published June 24, 2016  Taku Nishikawa, Eizo Yamamoto, Yoko Teraoku, Hideki Okada, Shigeto Shioya, Hiroshi L. Akazawa¹*   Abstract The objective of this study is investigated the protective effects of α-tocopherol on myocardial hypertrophy, […]

Pentoxifylline (PTX) attenuates LPS-induced acute liver injury via effects on ICAM-1 expression Pathophysiology of Cell Injury Journal  Volume 5, Issue 1, pages 26-39 Received November 11, 2015; accepted April 12, 2016; published June 19, 2016  Jia-bo Wang,Trisha Dezube, Margaret M. Kearney, Krishne MacLean*   Abstract Sepsis is characterized by up-regulation of inflammatory mediators in different pathways. Phosphodiesterase enzymes are often targets for many pharmacological […]

IL-36 expression plays a potential role in acute kidney injury through down-regulation of inflammatory response Pathophysiology of Cell Injury Journal  Volume 5, Issue 1, pages 16-26 Received December 01, 2015; accepted May 12, 2016; published June 11, 2016 Heather B. Hatcher¹, Yukio Tsung², Shao-Ling Qin¹’², Chris A Clarkson, Mao Zhao¹*   Abstract The inflammatory response following acute kidney injury (AKI) contributed in many pathological pathways that involved […]

Cytoplasmic double-stranded DNA trigger NALP3 after global myocardial I/R: crosstalk AIM2/ inflammasome      Pathophysiology of Cell Injury Journal  Volume 4, Issue 1, pages 1-12 Published: June 02, 2015 Michelle Caroline;Timothy Michelsen; David M. Lorenz; Kathrin A.Dorfmüller Abstract Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage […]

Mechanistic role of let -7c in breast cancer cell activity

doi: 10.18081/pcij/2378-5225/014-06/22-34      Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 22-34 June 2014 Michael Philip; Edwin Looney; Nasser Ghaly Yousif; Kim  A Schwager; Steven Sharma; Danielle D Paterson; Saija Burk; Kieran Radziwill; Schmittgen; Maria Eves; Giorgio Inoue; Douglas L Hainz Abstract Let-7 and its family members are highly conserved across species in sequence […]

The pathophysiology of inflammation in cell injury

      doi: 10.18081/pcij/2378-5225/014-06/01-09      Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 1-9 June 2014 Elizabeth Rispens, Amanda Bron, Julie Lee, Jimmy Fukumoto Abstract The purpose of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory […]

Critical role of NQO1 in ovarian cell injury: highly risk of ovarian carcinoma

      doi: 10.18081/pcij/2378-5225/012-12/01-09     Pathophysiology of Cell Injury Journal  Volume 1, Issue 1, pages 1-9 December 2012 Yu-Lin Yang, Yongzhang Wang, Junying Shyu, Nan Zhang  Abstract Chronic inflammation suppresses NAD(P)H quinone oxidoreductase1 (NQO1) expression and may increase susceptibility to cell injury. Paradoxically, increasing evidence suggests that high expression of NQO1 at the early stages […]

H2 therapy protects myocardial cell injury induce by sepsis via attenuated expression the level of HMGB1

    doi: 10.18081/pcij/2378-5225/012-12/10-19      Pathophysiology of Cell Injury Journal  Volume 1, Issue 1, pages 10-19 December 2012 Amy A Bravo; Krneta Kumm; Catalina Lamy; Jorge Jeanneau; Gisèle Cuello; Jack Lefer Abstract Sepsis involves a robust inflammatory response, involving up-regulated chemokine expression and leukocyte accumulation, contributes to the mechanism of myocardial injury and cardiac dysfunction. Currently, […]