Taku Nishikawa, Eizo Yamamoto, Yoko Teraoku, Hideki Okada, Shigeto Shioya, Hiroshi L. Akazawa¹*
The objective of this study is investigated the protective effects of α-tocopherol on myocardial hypertrophy, through suppression the angiogenesis process in rat model. Male Brown Norway (BN) rats (4–6 weeks old, 250–300 g) were randomly divided into four groups (n=15): control, exercise, treated with α-tocopherol (250 mg/kg), exercise + α-tocopherol, and exercise + vehicle (normal saline) group. The myocardial hypertrophy was induced by a standard protocol of voluntary exercise. Histological and immunohistochemistry analyses used to assessed myocardial tissue hypertrophy from 1st and 5th week performed, beside gene expression levels of angiogenesis molecules. Together, the presented data from this study demonstrated the other function of α-tocopherol in improved myocardial hypertrophy.
Keywords: α-Tocopherol; Myocardial hypertrophy; Immunohistochemistry
READ THE FULL ARTICLE
1. Access this article through your login credentials or your institution
2. Access this article through OpenAthens/Sign in
3. Purchase this article at rate $55.00 and received Full-Text/PDF
You will have online immediate access to article following the completion of this purchase and you may download and print a copy of each article for your personal use. Use the coding below to purchase your article as PDF by credit card, debit card, payball will be asked to supply your billing card information. Before continue with your purchase please read carefully BM–Publisher terms and conditions of purchase.
For any technique error please contact us and will be response to sending purchase article by email.
Thank you for visiting Pathophysiology of Cell Injury Journal. * = Required fields[contact-form-7 404 "Not Found"]