Critical role of NQO1 in ovarian cell injury: highly risk of ovarian carcinoma


Pathophysiology of Cell Injury Journal  Volume 1, Issue 1, pages 1-9 December 2012

Yu-Lin Yang, Yongzhang Wang, Junying Shyu, Nan Zhang 


Chronic inflammation suppresses NAD(P)H quinone oxidoreductase1 (NQO1) expression and may increase susceptibility to cell injury. Paradoxically, increasing evidence suggests that high expression of NQO1 at the early stages of carcinogenesis may provide cancer cells with a growth advantage. NQO1 was shown to be expressed at high levels in many solid tumors, and to date, the role of NQO1 in ovarian carcinoma remains unclear. In the present study, we investigated the role high expression of NQO1 in ovarian carcinoma. NQO1 protein expression was assessed using RT-PCR, and Western blotting in the human ovarian cancer cell lines. Our results indicate that ovarian carcinoma positively correlated with the expression and activity of NQO1 cells.

Keywords: NQO1; Ovarian carcinoma; Chronic inflammation; Cell injury

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