Jeffrey Foley, Antony Aryal, Liu Yan, Christopher Bell, Chung Tae-Young
Abstract
Proinflammatory cytokines play an important role in the development of cerebral reperfusion injury. During reperfusion, activated neutrophil interact with endothelial cells and release cytokines which mediate inflammation. Some conventional drugs have been shown in animal experiments to provide effective neuroprotection. Although the actual mechanism is still unclear. Our data are consistent with the concept that functional outcome after stroke is dependent on the immune cell composition which develops following ischemic brain injury. Furthermore; the present study showed the mechanism of reperfusion injury and the potential therapeutic strategies of Taurine.
Keywords: Brain cell injury; Cerebral ischemia and reperfusion; ICAM-1; Taurine
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