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Brain cell injury following cerebral ischemia and reperfusion: positive effects of ICAM-1/ neuroprotective role of Taurine

 

 
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Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 10-21 June 2014

Jeffrey Foley, Antony Aryal, Liu Yan, Christopher Bell, Chung Tae-Young

Abstract

Proinflammatory cytokines play an important role in the development of cerebral reperfusion injury. During reperfusion, activated neutrophil interact with endothelial cells and release cytokines which mediate inflammation. Some conventional drugs have been shown in animal experiments to provide effective neuroprotection. Although the actual mechanism is still unclear. Our data are consistent with the concept that functional outcome after stroke is dependent on the immune cell composition which develops following ischemic brain injury. Furthermore; the present study showed the mechanism of reperfusion injury and the potential therapeutic strategies of  Taurine.

Keywords: Brain cell injury; Cerebral ischemia and reperfusion; ICAM-1; Taurine


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