Category: Open Access

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Cytoplasmic double-stranded DNA trigger NALP3 after global myocardial I/R: crosstalk AIM2/ inflammasome

      http://dx.doi.org/10.18081/2378-5225/015-06/1-12      Pathophysiology of Cell Injury Journal  Volume 4, Issue 1, pages 1-12 Published: June 02, 2015 Michelle Caroline;Timothy Michelsen; David M. Lorenz; Kathrin A.Dorfmüller Abstract Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage […]

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Mechanistic role of let -7c in breast cancer cell activity

doi: 10.18081/pcij/2378-5225/014-06/22-34      Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 22-34 June 2014 Michael Philip; Edwin Looney; Nasser Ghaly Yousif; Kim  A Schwager; Steven Sharma; Danielle D Paterson; Saija Burk; Kieran Radziwill; Schmittgen; Maria Eves; Giorgio Inoue; Douglas L Hainz Abstract Let-7 and its family members are highly conserved across species in sequence […]

Cardiomyocyte injury: mechanism of doxorubicin toxicity effects

  doi: 10.18081/pcij/2378-5225/014-12/73-82      Pathophysiology of Cell Injury Journal  Volume 3, Issue 2, pages 73-82 December 2014 Monica Vlaia; Mariela Hoang; Veronica Urzúa; Hugo Scammells; Sevgi González-Hernández Abstract Doxorubicin is part of a group of anthracycline antibiotics used in many treatment of solid and hematological malignancy. Doxorubicin use is limited by cumulative, dose-related, progressive myocardial cell injury that may […]