Aiden R. Halstrom PhD, Marissa K. Delaney PhD, Julian T. Kessler PhD
Hypoxia-Inducible Factor-1α (HIF-1α) Modulation as a Strategy to Prevent Ischemic Cell Injury in the Heart
Wei Zhang, PhD · Min Li, PhD · Rui Chen, PhD
N-acetylcysteine attenuated sepsis-induced cardiac depression: down-regulation of MMP-2 pathway in mice
Nasser Ghaly Yousif¹*, Bassim I. Mohammad², Najah Hadi³, Musaed H. Al-Dahhan¹, Safa Al-khalidy¹ Author Affiliations *Corresponding Author: Electronic address: yousif_ghaly@yahoo.com. ¹Muthanna University School of Medicine. ²Qadyssia University. ³Department of Pharmacology, University of Kufa Abstract During sepsis, the inflammatory responses mediate myocardium injury, including LV dysfunction and cardiac pathophysiological changes. To understanding the pathway of […]
Potential activity of GIT-27 against renal ischemia reperfusion injury: an experimental study in male rats
Najah Hadi ¹*,Huda jabber ¹ Abstract The detail mechanisms in which renal ischemia reperfusion (IRI) happens are still indistinct. Various elements required in the pathogenesis include oxidative stress, inflammation, cellular necrosis, apoptosis, renal pathophysiological changes etc. To understand the pathway of ischemia reperfusion in renal we tested the hypothesis that GIT-27 attenuated renal […]
Angiotherapeutic effects of orciprenaline after ischemic spinal cord injury: down-regulation of MAPK signaling in animal model
http://dx.doi.org/10.18081/2378-5225-016-06/56-64 Pathophysiology of Cell Injury Journal Volume 5, Issue 1, pages 56-64 Received October 12, 2015; accepted May 02, 2016; published June 27, 2016 Christina Ballantyne¹’², Haohao Chen¹’³, Jin GAO¹, Liping Liu¹, Yongjun Lee¹* Abstract Because there is no curative treatment for ischemic spinal cord (SCI), investigating animal model is highlight to assess therapies for […]
α-Tocopherol improved myocardial hypertrophy through suppression angiogenesis process in rat model
http://dx.doi.org/10.18081/2378-5225-016-06/40-55 Pathophysiology of Cell Injury Journal Volume 5, Issue 1, pages 40-55 Received November 28, 2015; accepted April 30, 2016; published June 24, 2016 Taku Nishikawa, Eizo Yamamoto, Yoko Teraoku, Hideki Okada, Shigeto Shioya, Hiroshi L. Akazawa¹* Abstract The objective of this study is investigated the protective effects of α-tocopherol on myocardial hypertrophy, […]
Pentoxifylline (PTX) attenuates LPS-induced acute liver injury via effects on ICAM-1 expression
http://dx.doi.org/10.18081/2378-5225-016-06/26-39 Pathophysiology of Cell Injury Journal Volume 5, Issue 1, pages 26-39 Received November 11, 2015; accepted April 12, 2016; published June 19, 2016 Jia-bo Wang,Trisha Dezube, Margaret M. Kearney, Krishne MacLean* [citeby doi=”10.18081/2333-5225.2025.12.1.15″ label=”Cited by” button_show=”Show” button_hide=”Hide”] Abstract Sepsis is characterized by up-regulation of inflammatory mediators in different pathways. Phosphodiesterase enzymes are often targets for […]
IL-36 expression plays a potential role in acute kidney injury through down-regulation of inflammatory response
http://dx.doi.org/10.18081/2378-5225-016-06/16-26 Pathophysiology of Cell Injury Journal Volume 5, Issue 1, pages 16-26 Received December 01, 2015; accepted May 12, 2016; published June 11, 2016 Heather B. Hatcher¹, Yukio Tsung², Shao-Ling Qin¹’², Chris A Clarkson, Mao Zhao¹* Abstract The inflammatory response following acute kidney injury (AKI) contributed in many pathological pathways that involved […]
Comparison of maternal serum tumor necrosis Factor-Alpha in sever and mild pre-eclampsia versus normal pregnancy
http://dx.doi.org/10.18081/2378-5225-016-06/1-15 Pathophysiology of Cell Injury Journal Volume 5, Issue 1, pages 1-15 Received December 15, 2015; accepted May 02, 2016; published June 09, 2016 Azhar Mousa Al-Turiahi* Abstract Pre-eclampsia (PE) is an idiopathic disorder unique to pregnancy in human and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. […]
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