Protects against cell injury and infection: activation of immune system/AhR

Pathophysiology of Cell Injury Journal  Volume 3, Issue 2, pages 46-59 December 2014

Ashley H. Schrenk; Rimpei Abe; Malcolm Scammells; Philip Frugier


Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor is a ligand-activated transcription factor that serves as a receptor for various environmental toxins. The study used male mice between 6 and 12 wk of age, the viridans streptococcal 10403s and viridans streptococcal-expressing full-length OVA (viridans streptococcal/OVA) were grown on brain-heart infusion (BHI) agar plates (BD Bacto) and virulent stocks were maintained by repeated passage through B6 mice, and ELISAs kits for quantitative measurements of cytokine. The current study tested the hypothesis that AhR activation within cells inhibited their ability to bind bacteria to reduce invasion. The results of this study support the data that AhR activation within cells altered bacterial adherence or bacterial survival, and future studies will focus on early innate immune cell responses to explain host protection

Keywords: Infection; Cell injury; AhR; Cytokines

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1. Stevens EA, Mezrich JD, Bradfield CA. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 2009;127:299311. [PubMed]

2. Salomon JA, Wang H, Freeman MK, et al. The global burden of disease study 2010. Lancet 2013; 380:20532260. [Publisher]

3. Molin C, Montaner J, Abilleira S, et al. Timing of spontaneous recanalization and risk of hemorrhagic transformation in acute cardioembolic stroke. Stroke 2001; 32:1079–1084. [PubMed]

4. Petrulis JR, Perdew GH. The role of chaperone proteins in the receptaryl hydrocarbonor core complex. Chem Biol Interact 2002;141(1-2):25-40. [PubMed]

5.  Regulation of Survivin Stability by the Aryl Hydrocarbon Receptor-interacting Protein. J Biol Chem 2006:281:34 24721-24727. [abstract/Full-Text]

6. Stevens EA, Mezrich JD, Bradfield CA. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 2009; 127(3):299–311.

7. Hahn ME, Karchner SI, Shapiro MA, Perera SA. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci USA 1997; 94:13743–8. [PubMed]

8. Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch Biochem Biophys 2006; 450:67–77. [PubMed]

9. Schaldach CM, Riby J, Bjeldanes LF. Lipoxin A4: a new class of ligand for the Ah receptor. Biochemistry 1999; 38:7594–600. [PubMed]

10. Negishi T, Kato Y, Ooneda O et al. Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance. J Immunol 2005; 175:7348–56. [PubMed]

11. Nguyen LP, Bradfield CA. The saerch for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 2008;21:102–16. [PubMed]

12. Bohonowych JE, Denison MS. Persistent binding of ligands to the aryl hydrocarbon receptor. Toxicol Sci 2007; 98:99–109. [PubMed]

13. Bunger MK, Glover E, Moran SM, et al. Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in Mice Carrying a Mutation in the DNA Binding Domain of the Aryl Hydrocarbon Receptor. Toxicol Sci 2008;106:83–92. [PubMed]

14. Reyes H, Reisz-Porszasz S, Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992;256:1193–1195. [PubMed]

15. Guo J, Sartor M, Karyala S, et al. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol 2004; 194:79–89. 

16. Bacsi SG, Hankinson O. Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions. J. Biol. Chem 1996;271:8843–8850. [PubMed]

17.  Wilson CL, Safe S. Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses [see comments]. Toxicologic Pathology 1998;26:657–671. [PubMed]

18. Carver LA, Bradfield CA. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. Journal of Biological Chemistry. 1997;272:11452–11456. [PubMed]

19. Lahvis GP, Lindell SL, Thomas RS, et al. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc. Natl. Acad. Sci. USA. 2000;97:10442–10447. [PubMed]

20. Hankinson O. Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor.Arch Biochem Biophys 2005;433:379–386. [PubMed]

21. Lahvis G, Pyzalski RW, Glover E, Pitot HC, McElwee MK, Bradfield C. The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse. Mol. Pharmacol 2005;67:714–720. [PubMed]

22. Walisser JA, Glover E, Pande K, Liss AL, Bradfield CA. Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc. Natl. Acad. Sci. USA 2005;102:17858–17863. [PubMed]

23. Ikuta T, Tachibana T, Watanabe J, Yoshida M, Yoneda Y, Kawajiri K. Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor. J Biochem (Tokyo) 2000;127:503–509. [PubMed]

24. Powell-Coffman JA, Bradfield CA, Wood WB. Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. Proceedings of the National Academy of Sciences of the United States of America 1998;95:2844–2849.

25. Qin H, Powell-Coffman JA. The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Dev Biol 2004;270:64–75. [PubMed]

26. Tian Y, Ke S, Denison MS, Rabson AB, Gallo MA. Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem 1999;274:510–515. [PubMed]

27. Mimura J, Fujii-Kuriyama Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 2003;1619:263–268. [PubMed]

28. Schmidt JV, Su GH, Reddy JK, Simon MC, Bradfield CA. Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. USA 1996;93:6731–6736. [PubMed]


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