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Protects against cell injury and infection: activation of immune system/AhR

 
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Pathophysiology of Cell Injury Journal  Volume 3, Issue 2, pages 46-59 December 2014

Ashley H. Schrenk; Rimpei Abe; Malcolm Scammells; Philip Frugier

Abstract

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor is a ligand-activated transcription factor that serves as a receptor for various environmental toxins. The study used male mice between 6 and 12 wk of age, the viridans streptococcal 10403s and viridans streptococcal-expressing full-length OVA (viridans streptococcal/OVA) were grown on brain-heart infusion (BHI) agar plates (BD Bacto) and virulent stocks were maintained by repeated passage through B6 mice, and ELISAs kits for quantitative measurements of cytokine. The current study tested the hypothesis that AhR activation within cells inhibited their ability to bind bacteria to reduce invasion. The results of this study support the data that AhR activation within cells altered bacterial adherence or bacterial survival, and future studies will focus on early innate immune cell responses to explain host protection

Keywords: Infection; Cell injury; AhR; Cytokines

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