pcij-2248-1775655832 20260408134352 PCIJ bmpublisher@bmpublisher.net Pathophysiology of Cell Injury Journal Pathophysiology of Cell Injury Journal 2378-5225 15 1 2026 1 3 Rajesh Kumar Sharma Anjali Mehta Vivek Reddy Narayan Sneha Patel Myocardial cell injury is a central pathological process underlying acute myocardial infarction, ischemia–reperfusion injury, and inflammatory cardiomyopathies. Although ischemic and metabolic disturbances initiate cardiomyocyte damage, accumulating evidence indicates that immune-mediated inflammatory responses significantly amplify myocardial injury. Among immune populations, myeloid cells—including monocytes, macrophages, and neutrophils—play a dominant role in shaping the inflammatory microenvironment of the injured heart. Experimental murine studies have demonstrated that these cells exacerbate myocardial injury through cytokine production, oxidative stress, inflammasome activation, and direct cellular interactions with cardiomyocytes. Importantly, the temporal dynamics and phenotypic heterogeneity of myeloid cells critically determine whether inflammation promotes injury or facilitates repair. This review provides a comprehensive synthesis of the mechanisms by which myeloid cell–driven inflammation worsens myocardial cell injury in mice, with emphasis on molecular signaling pathways, immunometabolic regulation, and translational implications. Understanding these processes offers opportunities for targeted immunomodulatory therapies aimed at preserving myocardial integrity and improving clinical outcomes. 2026 1 3 10.18081/2378-5225/15.1 https://pcij.net/archives/2248