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Meloxicam attenuates brain cell injury following cerebral ischemia and reperfusion via down regulation of proinflammatory response Pathophsiology of Cell Injury Journal  Volume 1, Issue 1, pages 9-19 June 2013 Erik M. Loria; Cristina Schroeder; Polly Wallis; Michael B. Prendini Abstract    References 1. Stoll G, Kleinschnitz C, Nieswandt B. Combating innate inflammation: a new paradigm for […]

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Meloxicam attenuates brain cell injury following cerebral ischemia and reperfusion via down regulation of proinflammatory response

    doi: 10.18081/pcij/2378-5225/013-06/1-11    Pathophysiology of Cell Injury Journal  Volume 2, Issue 1, pages 1-11 June 2013 Erik M. Loria; Cristina Schroeder; Polly Wallis; Michael B. Prendini Abstract Stroke is the major cause of death and disability worldwide, and the thrombolytic therapy currently available was unsatisfactory. Meloxicam is a non-steroidal anti-inflammatory drug (NSAID), and little […]

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Brain cell injury following cerebral ischemia and reperfusion: positive effects of ICAM-1/ neuroprotective role of Taurine

      doi: 10.18081/pcij/2378-5225/014-06/10-21      Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 10-21 June 2014 Jeffrey Foley, Antony Aryal, Liu Yan, Christopher Bell, Chung Tae-Young Abstract Proinflammatory cytokines play an important role in the development of cerebral reperfusion injury. During reperfusion, activated neutrophil interact with endothelial cells and release cytokines which mediate […]

Cellular injury by over expression of Pin1/up-regulation in autoimmune disease

    doi: 10.18081/pcij/2378-5225/013-12/12-23   Pathophysiology of Cell Injury Journal  Volume 2, Issue 2, pages 12-23 December 2013 Mayuko Ding;  Kilian Smeal; Sam Orlicky;  Chuen PUmezawa;  Ying-Jiun Lee;  Cheng-Hsuan Umezawa Abstract Pin1 is a relatively small enzyme that contains an N-terminal WW domain that acts as a phosphoprotein-binding module and a C-terminal catalytic domain that is distinct from other conventional PPIases. Pin1-mediated post-phosphorylation regulation can have profound effects […]

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Registration of trials

Trial registration BM-Publisher journals uses the WHO definition of a clinical trial to decide what constitutes a clinical trial: “A clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. Interventions include (but are not restricted to) […]