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Mechanistic role of let -7c in breast cancer cell activity

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Pathophysiology of Cell Injury Journal  Volume 3, Issue 1, pages 22-34 June 2014

Michael Philip; Edwin Looney; Nasser Ghaly Yousif; Kim  A Schwager; Steven Sharma; Danielle D Paterson; Saija Burk; Kieran Radziwill; Schmittgen; Maria Eves; Giorgio Inoue; Douglas L Hainz

Abstract

Let-7 and its family members are highly conserved across species in sequence and function. They form an important class of regulators that participate in diverse biological functions including development, cell proliferation, differentiation, and apoptosisand, misregulation of let-7 leads to a less differentiated cellular state and the development of cell-based cancer. A growing body of evidence suggests that restoration of let-7 expression may be a useful therapeutic option in cancers, where its expression has been lost. Using breast cancer as a model, we have determined that breast cancer cells express high levels of the microRNA let-7, suggesting that let-7 is a marker for cancers. 

Keywords: microRNA; Cancer cell; Let-7c; Metastasis

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