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Cardiomyocyte injury: mechanism of doxorubicin toxicity effects

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Pathophysiology of Cell Injury Journal  Volume 3, Issue 2, pages 73-82 December 2014

Monica Vlaia; Mariela Hoang; Veronica Urzúa; Hugo Scammells; Sevgi González-Hernández

Abstract

Doxorubicin is part of a group of anthracycline antibiotics used in many treatment of solid and hematological malignancy. Doxorubicin use is limited by cumulative, dose-related, progressive myocardial cell injury that may lead to cardiotoxicity. The cardiotoxicity induced by doxorubicin appears to be a multi-factorial process and many mechanisms have been proposed and studied. The objective of this study is to approve the role of toll-like receptor (TLR)-3 in mechanism of doxorubicin toxicity. Wild-type male adult mice and knock-out mice were used. To investigated the role of TLR3, MAPK in the doxorubicin cardiotoxcity, MAPK protein assay by using western blot in mice. Taken together our findings demonstrate for the first time a relevant role of TLR3 in the development of doxorubicin induces cardiotoxicity under experimental condition. Further, studies using therapeutic interventions such as pharmacological TLR3 inhibition may be.

Keywords: Doxorubicin; MAPK/TRIF; Cardiac cell injury; Hemodynamic study

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