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IL-36 expression plays a potential role in acute kidney injury through down-regulation of inflammatory response

 
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http://dx.doi.org/10.18081/2378-5225-016-06/16-26
Pathophysiology of Cell Injury Journal  Volume 5, Issue 1, pages 16-26
Received December 01, 2015; accepted May 12, 2016; published June 11, 2016

Heather B. Hatcher¹, Yukio Tsung², Shao-Ling Qin¹’², Chris A Clarkson, Mao Zhao¹*

 

Abstract

The inflammatory response following acute kidney injury (AKI) contributed in many pathological pathways that involved in renal failure. IL-36 is member of the IL-1 family of cytokines and recently found it expressed in blood and correlated to the tissue injury. However, the role of IL-36 role in AKI remains unclear. This study investigated a potential role for IL-36 in down-regulation of the inflammatory response following AKI. Acute ischemia and reperfusion operation were performed sham on male C57BL/6J and IL-36-/- mice. The inflammatory response markly decreased with mice loss the IL-36, rsulted in suppression of (IL-6, IL-1ß, TN-alfa). The infiltration of peritubular neutrophils was attenuated in IL-36-/- mice with reduced the plasma levels of blood urea and serum creatinin, further data demonstrated that less apoptosis in IL-36-/- under AKI. This study discussed the possibility of protective role with antagonised the effects of IL-36 in AKI and more investigation needs.

Keywords: IL-36; Acute kidney injury; Neutrophils

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References

1. Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. American journal of kidney diseases. 2009;53(6):961-73. [PubMed]

2. Mehta RL, Pascual MT, Soroko S, et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney international 2004;66(4):1613-21. [PubMed]

3. Dinarello C, Arend,W, Sims J, et al. IL-1 family nomenclature. Nat. Immunol 2010;11:973. [Abstract/Full-Text]

4. Jacob DH, Zeng IU, Tsung Y, et al. Tpl2 exaggerated ischemic hepatic injury through induction of apoptosis: Downstream of caspase-9. American Journal of BioMedicine 2014;2(4):422–439. [Abstract/Full-Text]

5. Hsu CY, McCulloch CE, Fan D, Ordonez JD, Chertow GM, Go AS. Community-based incidence of acute renal failure. Kidney Int 2007;72(2):208-212. [Abstract/Full-Text]

6. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet 2005;365:417-430. [Abstract/Full-Text]

7. American Society of Nephrology Renal Research Report. J Am Soc Nephrol 2005;16:1886-19063. [PubMed]

8. Towne J, Sims J. IL-36 in psoriasis. Curr Opin Pharmacol 2012;12(4):486-90. [PubMed]

9. Obialo CI, Okonofua EC, Tayade AS, et al. Epidemiology of de novo acute renal failure in hospitalized African Americans: comparing community-acquired vs hospital-acquired disease. Arch Intern Med 2000;160:1309-1313. [PubMed]

10. Chertow GM, Burdick E, Honour M, et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005;16:3365-3370. [PubMed]

11. Hou SH, Bushinsky DA, Wish JB, Cohen JJ, Harrington JT. Hospital-acquired renal insufficiency: A prospective study. Am J Med 1983;74:243 -248. [PubMed]

12. Dagher PC, Herget-Rosenthal S, et al. Newly developed techniques to study and diagnose acute renal failure. J Am Soc Nephrol 2003;14:2188 -2198. [PubMed]

13. Smith GL, Vaccarino V, Kosiborod M, et al. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? J Card Fail 2003;9:13-25. [PubMed] 

14. Agarwal A, Nick HS. Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol 2000;11(5):965-73. [PubMed]

15. Paller MS. Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. The American journal of physiology 1988;255(3 Pt 2):F539-44 [PubMed]

16.Kezic A, Thaiss F, Becker JU, Tsui TY, Bajcetic M. Effects of everolimus on oxidative stress in kidney model of ischemia/reperfusion injury. American journal of nephrology 2013;37(4):291-301. [PubMed] 

17. Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 2005;294:813–818. [PubMed]

18. Gabay C, Towne JE. Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions. J Leukoc Biol 2015;97(4):645-52. [Abstract/Full-Text]

19. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005;16(11):3365-3370. [PubMed]

20. Vigne S, Palmer G, Lamacchia C, et al. IL-36R ligands are potent regulators of dendritic and T cells. Blood 2011;118:5813-5823. [PubMed]

21. Lamacchia C, Palmer G, Rodriguez E, Martin P, Vigne S, et al. The severity of experimental arthritis is independent of IL-36 receptor signaling. Arthritis Res Ther 2013;15:R38. [PubMed]

22. Pan G, Risser P, Mao W, et al. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Cytokine 2001;13:1-7. [PubMed]

23. Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005;23:479-490. [Abstract/Full-Text]

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